Dynamic regulation of adipose tissue metabolism in the domestic broiler chicken – an alternative model for studies of human obesity
نویسندگان
چکیده
Background The domestic chicken is an attractive, but underutilized, animal model for studies of adipose tissue biology, metabolism and obesity: 1.) like humans, chickens rely on liver rather than adipose tissue for the majority of de novo lipogenesis; 2.) quantitative trait loci (QTLs) linked to fatness in chickens contain genes implicated in human susceptibility to obesity and diabetes; 3.) chickens are naturally hyperglycemic and insulin resistant; and 4.) a broad selection of genetic models exhibiting a range of fatness are available. To date, however, little is known about regulation of adipose metabolism in this model organism.
منابع مشابه
Molecular and metabolic profiles suggest that increased lipid catabolism in adipose tissue contributes to leanness in domestic chickens.
Domestic broiler chickens rapidly accumulate fat and are naturally hyperglycemic and insulin resistant, making them an attractive model for studies of human obesity. We previously demonstrated that short-term (5 h) fasting rapidly upregulates pathways of fatty acid oxidation in broiler chickens and proposed that activation of these pathways may promote leanness. The objective of the current stu...
متن کاملMicroarray analysis of genes differentially expressed in the liver of lean and fat chickens.
Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver ...
متن کاملRelationship between white tea and adipose tissue metabolism: The importance and necessity of future research regarding the effect of white tea on fat oxidation, compared to other Kinds of tea: Letter to the Editor
Obesity is a complex multifactorial disease. The worldwide prevalence of obesity has doubled since 1980 to an extent that nearly a third of the world’s population is now classified as overweight or obese. On the other hand, sports scientists have suggested exercise for the prevention of further spread of this disease. In addition to exercise, the use of natural fat-burning supplements, such as ...
متن کاملتاثیر 12 هفته تمرینات مقاومتی بر سطوح آپلین، امنتین-1 و مقاومت به انسولین در زنان مسن دارای اضافه وزن مبتلا به دیابت نوع 2
Background and Objective: Nowadays, it has been recognized that Apelin and Omentin as the hormones secreted by adipose tissue, can be effective in regulating metabolism. The purpose of the present study was to determine the impact of 12 weeks of resistance training exercises on the Apelin, Omentin-1 levels and insulin resistance in overweight elderly women suffering from type 2 diabetes. Materi...
متن کاملHormonal regulation of leptin expression in broiler chickens.
Leptin, the polypeptide hormone encoded by the obese gene, is secreted by adipose tissue and has been shown to induce satiety and increase energy expenditure in mammals. In this study, we confirmed the presence of a leptin homolog in liver and adipose tissues of broiler chickens. Leptin expression was also detected in chicken embryonic liver and yolk sac. The effects of hormone treatment on lep...
متن کامل